[fusion_builder_container admin_label="Referenser (Desktop)" type="flex" hundred_percent="no" hundred_percent_height="no" hundred_percent_height_scroll="no" align_content="stretch" flex_align_items="stretch" flex_justify_content="center" hundred_percent_height_center_content="yes" equal_height_columns="no" container_tag="div" hide_on_mobile="small-visibility,medium-visibility,large-visibility" status="published" margin_top="0px" margin_bottom="0px" padding_top="0px" padding_right="0px" padding_bottom="0px" padding_left="0px" border_style="solid" box_shadow="no" box_shadow_blur="0" box_shadow_spread="0" overflow="visible" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" background_color="#ffffff" background_position="center center" background_repeat="no-repeat" fade="no" background_parallax="none" enable_mobile="no" parallax_speed="0.3" background_blend_mode="none" video_aspect_ratio="16:9" video_loop="yes" video_mute="yes" absolute="off" absolute_devices="small,medium,large" sticky="off" sticky_devices="small-visibility,medium-visibility,large-visibility" sticky_transition_offset="0" scroll_offset="0" animation_direction="left" animation_speed="0.3" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0" admin_toggled="no"][fusion_builder_row][fusion_builder_column type="1_1" type="1_1" layout="1_1" align_self="auto" content_layout="column" align_content="flex-start" valign_content="flex-start" content_wrap="wrap" center_content="no" target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" order_medium="0" order_small="0" spacing_left="0px" spacing_right="0px" margin_top="0px" margin_bottom="0px" padding_right_small="0" padding_top="0px" padding_right="0px" padding_bottom="0px" padding_left="0px" hover_type="none" border_style="solid" box_shadow="no" box_shadow_blur="0" box_shadow_spread="0" background_type="single" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" background_position="left top" background_repeat="no-repeat" background_blend_mode="none" filter_type="regular" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0" animation_direction="left" animation_speed="0.3" last="true" border_position="all" first="true" padding_left_small="0" padding_right_medium="12px" padding_left_medium="12px" min_height="" link=""][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" class="global-link-italic global-link-color global-link-underlined" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] *1. https://www.sciencedirect.com/ *2. https://www.sciencedirect.com/ *3. https://www.sciencedirect.com/ *4. https://www.sciencedirect.com/ [/fusion_text][fusion_separator style_type="single solid" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" flex_grow="0" top_margin="40px" bottom_margin="40px" alignment="center" sep_color="#000000" /][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]

[fusion_builder_container admin_label="Vanliga frågor (Desktop)" type="flex" hundred_percent="no" hundred_percent_height="no" hundred_percent_height_scroll="no" align_content="stretch" flex_align_items="stretch" flex_justify_content="center" hundred_percent_height_center_content="yes" equal_height_columns="no" container_tag="div" hide_on_mobile="small-visibility,medium-visibility,large-visibility" status="published" margin_top="0px" margin_bottom="0px" padding_top="0px" padding_right="0px" padding_bottom="0px" padding_left="0px" border_style="solid" box_shadow="no" box_shadow_blur="0" box_shadow_spread="0" overflow="visible" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" background_color="#ffffff" background_position="center center" background_repeat="no-repeat" fade="no" background_parallax="none" enable_mobile="no" parallax_speed="0.3" background_blend_mode="none" video_aspect_ratio="16:9" video_loop="yes" video_mute="yes" absolute="off" absolute_devices="small,medium,large" sticky="off" sticky_devices="small-visibility,medium-visibility,large-visibility" sticky_transition_offset="0" scroll_offset="0" animation_direction="left" animation_speed="0.3" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0" admin_toggled="no"][fusion_builder_row][fusion_builder_column type="1_1" type="1_1" layout="1_1" align_self="auto" content_layout="column" align_content="flex-start" valign_content="flex-start" content_wrap="wrap" center_content="no" target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" order_medium="0" order_small="0" spacing_left="0px" spacing_right="0px" margin_top="0px" margin_bottom="0px" padding_right_small="0" padding_top="0px" padding_right="0px" padding_bottom="0px" padding_left="0px" hover_type="none" border_style="solid" box_shadow="no" box_shadow_blur="0" box_shadow_spread="0" background_type="single" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" background_position="left top" background_repeat="no-repeat" background_blend_mode="none" filter_type="regular" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0" animation_direction="left" animation_speed="0.3" last="true" border_position="all" first="true" padding_left_small="0" padding_right_medium="12px" padding_left_medium="12px" min_height="" link=""][fusion_imageframe image_id="1244" max_width="200px" hover_type="none" align_medium="none" align_small="none" align="left" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" lightbox="no" linktarget="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" caption_style="off" caption_align_medium="none" caption_align_small="none" caption_align="none" caption_title_tag="2" animation_direction="left" animation_speed="0.3" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0"]https://stage.kvarka.se/wp-content/uploads/2021/12/faq.svg[/fusion_imageframe][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="6" fusion_font_family_title_font="EuclidFlex-BoldItalic" fusion_font_variant_title_font="400" font_size="16px" text_transform="none" text_shadow="no" text_shadow_blur="0" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] – Which horses can be vaccinated? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] All horses from 5 months. [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="6" fusion_font_family_title_font="LibreBaskerville-Italic" fusion_font_variant_title_font="400" font_size="16px" text_shadow="no" text_shadow_blur="0" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="default" animation_direction="left" animation_speed="0.3"] Vaccination is highly recommended for: [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="20px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Horses before competition, sales or possible exposure events. Horses in an area with known outbreaks of strangles The safety of the product has not yet been tested in pregnant mares and breeding stallions. [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="6" fusion_font_family_title_font="EuclidFlex-BoldItalic" fusion_font_variant_title_font="400" font_size="16px" text_transform="none" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="20px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] – Can I combine Strangvac with other vaccines? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="20px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] A decision to use Strangvac before or after any other veterinary product should be made on a case-by-case basis [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="6" fusion_font_family_title_font="EuclidFlex-BoldItalic" fusion_font_variant_title_font="400" font_size="16px" text_transform="none" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="20px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] – Should I vaccinate in an outbreak situation? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Not yet tested. [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Bold" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Some guidelines: [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Horses with clinical signs and those in contact should not be vaccinated Vaccinated horses that have not been in contact with cases Last dose >2 months: booster dose will maximize immunity Last dose <2 months: no booster required [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Bold" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Unvaccinated horses [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="20px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Start primary course: partial protection from 2 weeks after 2nd dose. [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="6" fusion_font_family_title_font="EuclidFlex-BoldItalic" fusion_font_variant_title_font="400" font_size="16px" text_transform="none" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="20px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] – Should I vaccinate young, old or non-competition horses? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="20px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Young and old horses are at highest risk of severe disease if they become infected with S. equi. Vaccination protects these susceptible horses from potential introductions of S. equi. Vaccination raises herd immunity, protecting all horses on the farm. Revaccinate every 6 months if not high risk to maintain memory response. [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="6" fusion_font_family_title_font="EuclidFlex-BoldItalic" fusion_font_variant_title_font="400" font_size="16px" text_transform="none" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="20px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] – Can a vaccinated horse become infected? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Vaccination prevents strangles in up to 94% of horses and reduces the onset and severity of signs (Robinson et al., 2020, Vaccine). [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Bold" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Some vaccinated horses may still become infected because: [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] High level of exposure to S. equi Higher natural susceptibility [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Bold" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Increasing the number of vaccinated horses on a farm can achieve herd immunity: [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Minimizes transmission and exposure of vaccinated horses [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="6" fusion_font_family_title_font="EuclidFlex-BoldItalic" fusion_font_variant_title_font="400" font_size="16px" text_transform="none" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="20px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] – For how long will my horse be protected from strangles? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="20px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Strangvac is a new vaccine and there is limited information on the length of protection. Vaccinated horses are known to be protected from challenge for 2 months after the 2nd dose (Robinson et al., 2020, Vaccine). Vaccinated horses have antibody responses that neutralize an important S. equi protein for 6 months after the 2nd dose (Righetti et al., submitted) Vaccinated horses have an immune memory for 12 months after the 2nd dose, which can be activated by another dose of Strangvac (Robinson et al., 2020, Vaccine) *1. [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="6" fusion_font_family_title_font="EuclidFlex-BoldItalic" fusion_font_variant_title_font="400" font_size="16px" text_transform="none" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="20px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] – Will my vaccinated horse test positive for strangles? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="20px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] NO: Strangvac does not contain live S. equi cells. Vaccinated horses will not test culture positive unless infected with Strep. equi. NO: Strangvac does not contain S. equi DNA. Vaccinated horses will not test PCR positive unless infected with Strep. Equi. NO: Strangvac does not contain the proteins used in the strangles blood test. Vaccinated horses will not test seropositive unless they have been exposed to Strep. equi. [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="6" fusion_font_family_title_font="EuclidFlex-BoldItalic" fusion_font_variant_title_font="400" font_size="16px" text_transform="none" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="20px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] – What kind of adverse events can I expect? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Bold" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Fever: [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] A transient rise in body temperature of up to 2.6 °C may occur for one to five days post-vaccination. [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Bold" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Injection site: [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Transient local tissue reactions characterized by heat, pain and swelling of up to 8 cm diameter may occur for one to five days post-vaccination. [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Bold" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Ocular: [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] An ocular discharge may occur for one to five days post-vaccination. [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Bold" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Loss of appetite and demeanour changes: [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="20px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Loss of appetite and demeanour changes may occur for one day post-vaccination. [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="6" fusion_font_family_title_font="EuclidFlex-BoldItalic" fusion_font_variant_title_font="400" font_size="16px" text_transform="none" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="20px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] – Will Strangvac protect against different variants? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Strangvac is based on the most prevalent variant of S. equi in Europe, BAPS2 . 456 of 457 (99.8% ) isolates of the dominant ST-151 variant were identical to Strangvac at 1,579 of 1,580 amino acids in Strangvac (remaining isolate also had a truncated CNE antigen) Strangvac was tested with, and shown to protect against, the second most prevalent variant of S. equi in Europe, BAPS5 = heterologous challenge All 137 BAPS5 isolates shared 1,579 of the 1,580 amino acids of Strangvac [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] Do you have any questions? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" class="global-link-italic global-link-color global-link-underlined" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Pleace donat hesitate to ask if you have additional questions: strangvacfragor@kvarka.se [/fusion_text][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]

[fusion_builder_container admin_label="Användning" type="flex" hundred_percent="no" hundred_percent_height="no" hundred_percent_height_scroll="no" align_content="stretch" flex_align_items="stretch" flex_justify_content="center" hundred_percent_height_center_content="yes" equal_height_columns="no" container_tag="div" hide_on_mobile="small-visibility,medium-visibility,large-visibility" status="published" margin_top="0px" margin_bottom="0px" padding_top="0px" padding_right="0px" padding_bottom="0px" padding_left="0px" border_style="solid" box_shadow="no" box_shadow_blur="0" box_shadow_spread="0" overflow="visible" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" background_color="#ffffff" background_position="center center" background_repeat="no-repeat" fade="no" background_parallax="none" enable_mobile="no" parallax_speed="0.3" background_blend_mode="none" video_aspect_ratio="16:9" video_loop="yes" video_mute="yes" absolute="off" absolute_devices="small,medium,large" sticky="off" sticky_devices="small-visibility,medium-visibility,large-visibility" sticky_transition_offset="0" scroll_offset="0" animation_direction="left" animation_speed="0.3" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0" admin_toggled="no"][fusion_builder_row][fusion_builder_column type="1_1" type="1_1" layout="1_1" align_self="auto" content_layout="column" align_content="flex-start" valign_content="flex-start" content_wrap="wrap" center_content="no" target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" order_medium="0" order_small="0" spacing_left="0px" spacing_right="0px" margin_top="0px" margin_bottom="0px" padding_top="0px" padding_right="0px" padding_bottom="0px" padding_left="0px" hover_type="none" border_style="solid" box_shadow="no" box_shadow_blur="0" box_shadow_spread="0" background_type="single" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" background_position="left top" background_repeat="no-repeat" background_blend_mode="none" filter_type="regular" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0" animation_direction="left" animation_speed="0.3" last="true" border_position="all" first="true" padding_right_small="0" padding_left_small="0" padding_right_medium="12px" padding_left_medium="12px" min_height="" link=""][fusion_imageframe image_id="1230" max_width="800px" hover_type="none" align_medium="none" align_small="none" align="left" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" lightbox="no" linktarget="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" caption_style="off" caption_align_medium="none" caption_align_small="none" caption_align="none" caption_title_tag="2" animation_direction="left" animation_speed="0.3" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0"]https://stage.kvarka.se/wp-content/uploads/2021/12/Nålar.svg[/fusion_imageframe][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] Vaccinationsschema [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Bold" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Primary course: [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] According to SPC 1st vaccination: from 8 months (5 months in UK) of age. 2nd vaccination: 4 weeks later Additional published studies (LINK to efficacy data shown above): 3rd vaccination 3 months after the 2nd increases protection significantly1 (Robinson m.fl., 2020, Vaccine) *1. [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top_small="40px" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] Re-vaccination [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Data for prolonged clinical protection from the administration of single dose revaccinations are currently not available. However, IdeE activity is still neutralized 6 months after 2nd vaccination2 (Righetti et al., submitted) and an immunological memory response is maintained for up to 12 months after primary vaccination (Robinson m.fl. 2020) *1. In horses at high risk, according to SPC, it is recommended to repeat the primary course after 2 months post-last vaccination [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3" margin_top_small="40px"] Administration [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Administer one dose (2 ml) by intramuscular injection. [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3" margin_top_small="40px"] Storage [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Regular" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] Store and transport refrigerated (2 °C – 8 °C). Do not freeze. Keep the vial in the outer carton in order to protect from light [/fusion_text][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]

[fusion_builder_container admin_label="Effektivitet och säkerhet" type="flex" hundred_percent="no" hundred_percent_height="no" hundred_percent_height_scroll="no" align_content="stretch" flex_align_items="stretch" flex_justify_content="center" hundred_percent_height_center_content="yes" equal_height_columns="no" container_tag="div" hide_on_mobile="small-visibility,medium-visibility,large-visibility" status="published" margin_top="0px" margin_bottom="0px" padding_top="0px" padding_right="0px" padding_bottom="0px" padding_left="0px" border_style="solid" box_shadow="no" box_shadow_blur="0" box_shadow_spread="0" overflow="visible" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" background_color="#ffffff" background_position="center center" background_repeat="no-repeat" fade="no" background_parallax="none" enable_mobile="no" parallax_speed="0.3" background_blend_mode="none" video_aspect_ratio="16:9" video_loop="yes" video_mute="yes" absolute="off" absolute_devices="small,medium,large" sticky="off" sticky_devices="small-visibility,medium-visibility,large-visibility" sticky_transition_offset="0" scroll_offset="0" animation_direction="left" animation_speed="0.3" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0" admin_toggled="no"][fusion_builder_row][fusion_builder_column type="1_1" layout="1_1" align_self="auto" content_layout="column" align_content="flex-start" valign_content="flex-start" content_wrap="wrap" center_content="no" target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" order_medium="0" order_small="0" spacing_left="0px" spacing_right="0px" margin_top="0px" margin_bottom="0px" padding_top="0px" padding_right="0px" padding_bottom="0px" padding_left="0px" hover_type="none" border_style="solid" box_shadow="no" box_shadow_blur="0" box_shadow_spread="0" background_type="single" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" background_position="left top" background_repeat="no-repeat" background_blend_mode="none" filter_type="regular" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0" animation_direction="left" animation_speed="0.3" last="true" border_position="all" first="true" padding_right_small="0" padding_left_small="0" padding_right_medium="12px" padding_left_medium="12px" min_height="" link=""][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" class="global-link-italic global-link-color" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] Onset of immunity [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" class="global-link-italic global-link-color" margin_top="30px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] The onset of immunity is 2 weeks after the 2nd vaccination dose, with the 2nd vaccination administered 4 weeks after the 1st vaccination. [/fusion_text][fusion_accordion type="" inactive_icon="" active_icon="" hide_on_mobile="small-visibility,medium-visibility,large-visibility" class="" id="" boxed_mode="" border_size="1" border_color="" hue="" saturation="" lightness="" alpha="" background_color="" hover_color="" divider_line="no" divider_color="" divider_hover_color="" fusion_font_family_title_font="" fusion_font_variant_title_font="" title_font_size="" title_color="" icon_size="1" icon_color="rgba(255,255,255,0)" icon_boxed_mode="" icon_box_color="rgba(33,41,52,0)" icon_alignment="" fusion_font_family_content_font="" fusion_font_variant_content_font="" content_font_size="" content_color="" toggle_hover_accent_color="rgba(0,188,212,0)" toggle_active_accent_color=""][fusion_toggle title="" open="no" class="" id="" fusion_font_family_title_font="" fusion_font_variant_title_font="" title_font_size="" title_color="" hue="" saturation="" lightness="" alpha="" fusion_font_family_content_font="" fusion_font_variant_content_font="" content_font_size="" content_color=""] Study “Onset of immunity post 2nd vaccination” (Robinson et al., 2020) *1 Design of the study 32 ponies: 16 vaccinated, 16 controls Vaccinated group: vaccinated with Strangvac 2ml IM Control group: vaccinated with placebo control vaccine (containing adjuvant only) Challenge with S. equi strain Se4047, 5×10-7 cfu into each nostril Results Strangvac is effective from 2 weeks post-2nd vaccination: 100% of control ponies (n = 16) developed strangles Reduction of signs in 31% of Strangvac ponies (no pyrexia in 5/16, P = 0.04) Reduced severity and slower onset of acute disease Fewer lymph node abscesses This graph shows body temperature. 11 of 16 vaccinated ponies became pyretic, but the onset was delayed giving more time to vets to isolate affected horses before shedding of S. equi began. This graph shows the number of lymph node abscesses, which were significantly fewer in Strangvac-vaccinated ponies. [/fusion_toggle][/fusion_accordion][fusion_separator style_type="single solid" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" flex_grow="0" top_margin="30px" bottom_margin="0px" alignment="center" sep_color="#00b7ce" /][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" class="global-link-italic global-link-color" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] Duration of immunity [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" class="global-link-italic global-link-color" margin_top="30px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] After the primary course of 2 vaccinations, the duration of immunity has been shown to last for 2 months. [/fusion_text][fusion_accordion type="" inactive_icon="" active_icon="" hide_on_mobile="small-visibility,medium-visibility,large-visibility" class="" id="" boxed_mode="" border_size="1" border_color="" hue="" saturation="" lightness="" alpha="" background_color="" hover_color="" divider_line="no" divider_color="" divider_hover_color="" fusion_font_family_title_font="" fusion_font_variant_title_font="" title_font_size="" title_color="" icon_size="1" icon_color="rgba(255,255,255,0)" icon_boxed_mode="" icon_box_color="rgba(33,41,52,0)" icon_alignment="" fusion_font_family_content_font="" fusion_font_variant_content_font="" content_font_size="" content_color="" toggle_hover_accent_color="rgba(0,188,212,0)" toggle_active_accent_color=""][fusion_toggle title="" open="no" class="" id="" fusion_font_family_title_font="" fusion_font_variant_title_font="" title_font_size="" title_color="" hue="" saturation="" lightness="" alpha="" fusion_font_family_content_font="" fusion_font_variant_content_font="" content_font_size="" content_color=""] Study: ”Duration of immunity post-2nd vaccination” (Robinson m.fl., 2020) *1 Design of the study 16 ponies: 12 vaccinated, 4 controls Vaccinated group: vaccinated with Strangvac 2ml IM Control group: vaccinated with placebo control vaccine (containing adjuvant only) Challenge with S. equi strain Se4047, 5×10-7 cfu into each nostril Results Strangvac is effective at 2 months post-2nd vaccination. 100% of placebo ponies (n = 4) developed strangles Reduction of signs in 58% of Strangvac ponies (no pyrexia in 7/12, P = 0.09) Reduced severity and onset of acute disease including fewer lymph node abscesses This graph shows body temperature. 11 of 16 vaccinated ponies became pyretic, but the onset was delayed giving more time to vets to isolate affected horses before shedding of S. equi began. This graph shows the number of lymph node abscesses, which were significantly fewer in Strangvac-vaccinated ponies. [/fusion_toggle][/fusion_accordion][fusion_separator style_type="single solid" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" flex_grow="0" top_margin="30px" bottom_margin="0px" alignment="center" sep_color="#00b7ce" /][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" class="global-link-italic global-link-color" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] Additional efficacy data [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" class="global-link-italic global-link-color" margin_top="30px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] IdeE activity is still neutralized by sera from ponies 6 months after 2nd vaccination with Strangvac. (Righetti et al., 2021, Equine Veterinary Journal). [/fusion_text][fusion_accordion type="" inactive_icon="" active_icon="" hide_on_mobile="small-visibility,medium-visibility,large-visibility" class="" id="" boxed_mode="" border_size="1" border_color="" hue="" saturation="" lightness="" alpha="" background_color="" hover_color="" divider_line="no" divider_color="" divider_hover_color="" fusion_font_family_title_font="" fusion_font_variant_title_font="" title_font_size="" title_color="" icon_size="1" icon_color="rgba(255,255,255,0)" icon_boxed_mode="" icon_box_color="rgba(33,41,52,0)" icon_alignment="" fusion_font_family_content_font="" fusion_font_variant_content_font="" content_font_size="" content_color="" toggle_hover_accent_color="rgba(0,188,212,0)" toggle_active_accent_color=""][fusion_toggle title="" open="no" class="" id="" fusion_font_family_title_font="" fusion_font_variant_title_font="" title_font_size="" title_color="" hue="" saturation="" lightness="" alpha="" fusion_font_family_content_font="" fusion_font_variant_content_font="" content_font_size="" content_color=""] Study: ”IdeE activity post-vaccination” (Righetti m.fl., ny studie) *2 IdeE cleaves immunoglobulin, protecting S. equi from the immune response (Lannergård and Guss 2006, FEMS Microbiol. Lett. and Hulting at el., 2009, FEMS Microbiol. Lett.). Addition of IdeE increased the protection provided by prototype vaccines in ponies (Guss et al., 2009, PLoS Pathogens). Design of the study 43 ponies: 28 vaccinated, 15 controls Vaccinated group: vaccinated with Strangvac 2ml IM 3 times, with 3rd dose given at 3, 6 or 12 months after 2nd vaccination. Control group: vaccinated with placebo control vaccine (containing adjuvant only) Serum samples were used to measure anti-IdeE responses by conventional iELISA and the neutralisation of the cleavage of antibodies by IdeE using a western blot-based assay. Results IdeE activity is still neutralized by sera from ponies 6 months after 2nd vaccination (Righetti et al., new paper). After the 2nd dose an immune memory is generated that lasts for 12 months. Revaccination within this time frame generates a similar antibody response in blood and nasal secretions as that seen after the 2nd vaccination. Study “Antibody response in serum and nasal secretions after 3 vaccinations (3rd dose given 3, 6 or 12 months after 2nd dose)” (Robinson et al., 2020) *1 Design of the study 12 ponies, all vaccinated Vaccinated group: vaccinated with Strangvac 2ml IM Antibody response to all 3 vaccine components measured in serum and nasal wash samples Results Vaccinated horses have an immune memory for 12 months after the 2nd dose, which can be activated by another dose of Strangvac. The graphs below show levels of different types of antibodies in serum and nasal wash samples: Strangvac induced antibody responses in blood serum and nasal secretions Responses remained elevated post-vaccination and were boosted after 3, 6 or 12 months Administration of a 3rd vaccination dose 3 months after the 2nd dose has been shown to significantly increase the level of protection as compared to 2 doses. Study: ”Enhanced immunity post-3rd vaccination” (Robinson m.fl., 2020) *1 Design of the study 31 ponies: 16 vaccinated, 15 controls Vaccinated group: vaccinated with Strangvac 2ml IM Control group: vaccinated with placebo control vaccine (containing adjuvant only) Challenge with S. equi strain Se4047, 5×10-7 cfu into each nostril. Results A 3rd vaccination 3 months after the 2nd increases protection significantly to 94% efficacy. 100% of control ponies (n = 15) developed strangles Reduction of signs in 94% of Strangvac ponies (no pyrexia in 15/16, P No lymph node abscesses in 94% of Strangvac ponies, P = 0.00001 This graph shows body temperature. Only one vaccinated pony became pyretic. This graph shows the number of lymph node abscesses. Only one Strangvac-vaccinated pony developed an abscess. [/fusion_toggle][/fusion_accordion][fusion_separator style_type="single solid" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" flex_grow="0" top_margin="30px" bottom_margin="0px" alignment="center" sep_color="#00b7ce" /][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" class="global-link-italic global-link-color" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top_small="40px" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] Safety [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="30px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] Strangvac is tested safe for use in horses from the age of 5 months. Strangvac does NOT contain live bacteria, and therefore cannot cause strangles as has been reported with the use of live vaccines (Livengood et al., 2016, Vaccine; Cursons et al., 2015, Vaccine; Newton et al., 2005, Vet Rec; Kelly et al., 2006, J Clin Microbiol, Harris et al., 2015, Genome Research; Mitchell et al., 2021, Microbial Genomics)*4 [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" class="global-link-italic global-link-color" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3" margin_top_small="40px"] Adverse effect [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="30px" margin_right="0px" margin_bottom="0px" margin_left="0px" fusion_font_family_text_font="LibreBaskerville-Italic" fusion_font_variant_text_font="400" text_transform="none" animation_direction="left" animation_speed="0.3"] The following adverse reactions can be seen after vaccination with Strangvac: [/fusion_text][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] Transient increase in body temperature of up to 2.6°C for one to five days (very common) Transient local tissue reactions at the injection site, characterised by heat, pain and swelling (approximately 5 cm diameter) (very common) Loss of appetite and demeanour changes for one day (common). Ocular discharge which may be mucopurulent and present from both eyes (very common) Anaphylactic-like reactions occur in very rare cases. For a full description of adverse reaction please consult the SPC. [/fusion_text][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]

[fusion_builder_container admin_label="Det finns ett vaccin" type="flex" hundred_percent="no" hundred_percent_height="no" hundred_percent_height_scroll="no" align_content="stretch" flex_align_items="stretch" flex_justify_content="center" hundred_percent_height_center_content="yes" equal_height_columns="no" container_tag="div" hide_on_mobile="small-visibility,medium-visibility,large-visibility" status="published" margin_top="0px" margin_bottom="0px" padding_top="0px" padding_right="0px" padding_bottom="0px" padding_left="0px" border_style="solid" box_shadow="no" box_shadow_blur="0" box_shadow_spread="0" overflow="visible" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" background_color="#ffffff" background_position="center center" background_repeat="no-repeat" fade="no" background_parallax="none" enable_mobile="no" parallax_speed="0.3" background_blend_mode="none" video_aspect_ratio="16:9" video_loop="yes" video_mute="yes" absolute="off" absolute_devices="small,medium,large" sticky="off" sticky_devices="small-visibility,medium-visibility,large-visibility" sticky_transition_offset="0" scroll_offset="0" animation_direction="left" animation_speed="0.3" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0"][fusion_builder_row][fusion_builder_column type="1_1" type="1_1" layout="1_1" align_self="auto" content_layout="column" align_content="flex-start" valign_content="flex-start" content_wrap="wrap" center_content="no" target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" order_medium="0" order_small="0" spacing_left="0px" spacing_right="0px" margin_top="0px" margin_bottom="0px" padding_top="0px" padding_right="0px" padding_bottom="0px" padding_left="0px" hover_type="none" border_style="solid" box_shadow="no" box_shadow_blur="0" box_shadow_spread="0" background_type="single" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" background_position="left top" background_repeat="no-repeat" background_blend_mode="none" filter_type="regular" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0" animation_direction="left" animation_speed="0.3" last="true" border_position="all" first="true" padding_right_small="0" padding_left_small="0" padding_right_medium="12px" padding_left_medium="12px" min_height="" link=""][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="0px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] Strangvac is an intramuscular vaccine against strangles and is indicated to reduce the clinical signs and the number of abscesses within submandibular and retropharyngeal lymph nodes in horses during the acute stage of strangles. Clinical signs include: body temperature increase, coughing, difficulty swallowing, and signs of depression (inappetence, changes in demeanour). [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top_small="40px" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3"] Which technology is used in strangvac? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] Strangvac uses innovative recombinant fusion protein technology. DNA fragments encoding 8 important Strep. equi proteins are joined together to make 3 synthetic ‘genes’ and each is placed into Escherichia coli bacteria. The Escherichia coli is grown in fermenter cultures and uses the synthetic genes as a blueprint to make each protein. The fermented Escherichia coli is then lysed and each protein is extracted and purified ready for use in Strangvac. It is key to note that Strangvac contains no Strep. equi bacteria nor DNA and therefore has DIVA capability. [/fusion_text][fusion_imageframe image_id="2318" custom_aspect_ratio="100" lightbox="no" linktarget="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" align_medium="none" align_small="none" align="none" hover_type="none" caption_style="off" caption_align_medium="none" caption_align_small="none" caption_align="none" caption_title_tag="2" animation_direction="left" animation_speed="0.3" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0"]https://stage.kvarka.se/wp-content/uploads/2022/02/what-technic-eng.svg[/fusion_imageframe][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3" margin_top_small="40px"] Which strep. Equi antigens are included in strangvac? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] Strangvac contains the following proteins: Recombinant protein CCE, comprised of Strep. equi antigens CNE, SclF, SclI, SclC, EAG Recombinant protein Eq85, comprised of Strep. equi antigens: Eq5, Eq8 Recombinant protein IdeE, comprised of Strep. equi antigen IdeE [/fusion_text][fusion_imageframe image_id="2467" custom_aspect_ratio="100" lightbox="no" linktarget="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" align_medium="none" align_small="none" align="none" hover_type="none" caption_style="off" caption_align_medium="none" caption_align_small="none" caption_align="none" caption_title_tag="2" animation_direction="left" animation_speed="0.3" filter_hue="0" filter_saturation="100" filter_brightness="100" filter_contrast="100" filter_invert="0" filter_sepia="0" filter_opacity="100" filter_blur="0" filter_hue_hover="0" filter_saturation_hover="100" filter_brightness_hover="100" filter_contrast_hover="100" filter_invert_hover="0" filter_sepia_hover="0" filter_opacity_hover="100" filter_blur_hover="0"]https://stage.kvarka.se/wp-content/uploads/2022/02/what-antigenes-swe-1.svg[/fusion_imageframe][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] These antigens, with the exception of IdeE, are localised on the bacterial surface and antibodies against them are assumed to be opsonic and block bacterial adherence to tissue surfaces and the ability of these important proteins to help Strep. equi to cause disease. The seven cell wall proteins are surface-anchored to the peptidoglycan bacterial cell wall. CNE binds collagen1 and Strangvac responses blocked the attachment of Strep. equi to collagen (Flock et al., unpublished data). EAG binds alpha 2-macroglobulin, serum albumin and IgG2, 3. The function of SclF, SclI, SclC, Eq5 and Eq8 are currently unknown, but likely to not only be involved in adhesion as many of these classes of proteins have multiple functions in mis-directing host immune responses. Interestingly, SclF, SclI, SclC and Eq8 are each individually essential to Strep. equi in order for it to cause strangles in horses (Charbonneau et al., unpublished data). Therefore, the immune responses generated by Strangvac target Strep. equi for killing, but also block key virulence functions, making it easier for the immune response to kill Strep. equi. [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="3" text_transform="uppercase" text_shadow="no" text_shadow_blur="0" margin_top="40px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="none" animation_direction="left" animation_speed="0.3" margin_top_small="40px"] Does strangvac protect against all field strains of strep. Equi? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] The antigens in Strangvac are extremely well conserved and Strangvac is expected to protect against all variants of Strep. equi that currently circulate worldwide (Frosth et al., new paper). All 759 strains examined in this survey had at least 6 identical antigens to the 8 in Strangvac. 98% of strains had none or only one amino acid variation relative to the 1580 amino acids that make up the 8 antigens in Strangvac. Strangvac is based on BAPS2 strain (the most prevalent cause of strangles in Europe) and the studies that determined the effectiveness of Strangvac used a heterologous BAPS5 strain, which is the second most prevalent type of Strep. equi in Europe. [/fusion_text][fusion_title title_type="text" rotation_effect="bounceIn" display_time="1200" highlight_effect="circle" loop_animation="off" highlight_width="9" highlight_top_margin="0" title_link="off" link_target="_self" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" content_align="left" size="6" fusion_font_family_title_font="EuclidFlex-MediumItalic" fusion_font_variant_title_font="400" font_size="16px" text_shadow="no" text_shadow_blur="0" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" gradient_font="no" gradient_start_position="0" gradient_end_position="100" gradient_type="linear" radial_direction="center center" linear_angle="180" style_type="default" animation_direction="left" animation_speed="0.3"] – Will a Strangvac-vaccinated horse test positive for strangles? [/fusion_title][fusion_text rule_style="default" hide_on_mobile="small-visibility,medium-visibility,large-visibility" sticky_display="normal,sticky" margin_top="20px" margin_right="0px" margin_bottom="0px" margin_left="0px" text_transform="none" animation_direction="left" animation_speed="0.3"] No, Strangvac does not contain live Strep. equi, nor Strep. equi DNA. Therefore horses that have been vaccinated with Strangvac will not test positive in culture tests or PCR tests, unless they have been recently infected with Strep. equi. In addition, Strangvac does not contain the proteins used in the strangles blood test. Therefore, vaccinated horses will not test seropositive unless they have been exposed to Strep. equi. This means that Strangvac, unlike other strangles vaccines, possesses DIVA capability (DIVA = Differentiating Infected from Vaccinated Animals). [/fusion_text][/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]

FAQs arkiv - Kvarka.se

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*1. https://www.sciencedirect.com/ *2. https://www.sciencedirect.com/ *3. https://www.sciencedirect.com/ *4. https://www.sciencedirect.com/ [...]

By Andreas|2022-03-05T08:14:38+00:0028 January, 2022|0 Comments

* REFERENCES

*1. https://www.sciencedirect.com/ *2. https://www.sciencedirect.com/ *3. https://www.sciencedirect.com/ *4. https://www.sciencedirect.com/ [...]

By Andreas|2022-03-05T08:12:14+00:0016 December, 2021|0 Comments

FAQ

– Which horses can be vaccinated? All horses [...]

By Andreas|2022-03-05T08:11:10+00:0016 December, 2021|For vets|0 Comments

HOW TO USE

Vaccinationsschema Primary course: According to SPC 1st [...]

By Andreas|2022-03-05T08:09:26+00:0016 December, 2021|For vets, For vets, For vets, For vets, For vets|0 Comments

EFFICACY AND SAFETY

Onset of immunity The onset of immunity is [...]

By Andreas|2022-03-24T10:03:59+00:0016 December, 2021|0 Comments

WHAT IS STRANGVAC

Strangvac is an intramuscular vaccine against strangles and is [...]

By Andreas|2022-03-05T08:05:40+00:0016 December, 2021|0 Comments

ADDITIONAL INFORMATION

Additional information about strangles disease, outbreak management and disease [...]

By Andreas|2022-03-05T08:02:48+00:0015 December, 2021|0 Comments

HOW TO CONFIRM STRANGLES BY DIAGNOSTIC TESTING

Culture test, PCR and ELISA

By Andreas|2022-03-05T08:00:55+00:0015 December, 2021|For Horse Owners|0 Comments

WORLDWIDE PREVALENCE OF STRANGLES

Strangles is one of the most frequently diagnosed infectious [...]

By Andreas|2022-03-05T07:27:47+00:0015 December, 2021|For Horse Owners, For Horse Owners, For Horse Owners|0 Comments

HOW TO DEAL WITH A OUTBREAK SITUATION AND HOW TO TREAT STRANGLES

What to do when a horse has strangles in [...]

By Andreas|2022-03-05T07:22:13+00:0015 December, 2021|0 Comments

Kvarka.se är ett initiativ från Intervacc i syfte att stoppa kvarka innan det når hästen.
Tillsammans kan vi stoppa kvarka!

Kvarka.se är ett initiativ från Intervacc i syfte att stoppa kvarka innan det når hästen.
Tillsammans kan vi stoppa kvarka!

Kvarka.se är ett initiativ från Intervacc i syfte att stoppa kvarka innan det når hästen. Tillsammans kan vi stoppa kvarka!

Kvarka.se är ett initiativ från Intervacc i syfte att stoppa kvarka innan det når hästen. Tillsammans kan vi stoppa kvarka!

Kvarka.se är ett initiativ från Intervacc i syfte att stoppa kvarka innan det når hästen.
Tillsammans kan vi stoppa kvarka!

Kvarka.se är ett initiativ från Intervacc i syfte att stoppa kvarka innan det når hästen.
Tillsammans kan vi stoppa kvarka!